Joki-Korpela P, Hyypiä T
Haartman Institute, Department of Virology, University of Helsinki, Finland.
Ann Med. 2001 Oct;33(7):466-71. doi: 10.3109/07853890109002095.
Parechoviruses are a recently established group of human viral pathogens. At the time of their first isolation, parechoviruses were classified among the enterovirus genus in the picornavirus family, but based on their different biological properties they were separated into their own genus. The type member is human parechovirus 1 (HPEV1), which frequently infects humans, in particular small children. The parechovirus genus also includes HPEV2 and the Ljungan virus, which was recently isolated from rodents, is a candidate for the group. Seroepidemiological studies have shown that the prevalence of HPEV1 antibodies is surprisingly high, exceeding 95% in adult populations. According to present data, HPEV1 causes mainly gastrointestinal and respiratory infections; however, severe disease conditions, such as myocarditis and encephalitis, have also been reported. HPEV2 infections appear to be rare, and it is currently not known whether the Ljungan virus can infect humans.
细小病毒是一组最近确定的人类病毒病原体。在首次分离时，细小病毒被归类于小核糖核酸病毒科的肠道病毒属，但基于它们不同的生物学特性，它们被分离成了自己的属。该属的典型成员是人类细小病毒1型（HPEV1），它经常感染人类，尤其是幼儿。细小病毒属还包括HPEV2，最近从啮齿动物中分离出的吕宋病毒也是该属的候选成员。血清流行病学研究表明，HPEV1抗体的流行率出奇地高，在成年人群中超过95%。根据目前的数据，HPEV1主要引起胃肠道和呼吸道感染；然而，也有报道称其会导致严重疾病，如心肌炎和脑炎。HPEV2感染似乎很少见，目前尚不清楚吕宋病毒是否能感染人类。
