Raymond S L, Dodds W J
Thromb Diath Haemorrh. 1975 Apr 30;33(2):361-9.
A large colony of fawn-hooded (FH) rats, comprising five original families and six generations of their progeny, was developed for genetic and comparative studies of their bleeding tendency. The characteristics of the bleeding diathesis in these rats are similar to those originally reported in related rats by Tschopp and Zucker. FH rats have normal clot retraction, ADP-induced platelet aggregation and platelet ADP; variable aggregation with collagen; minimal aggregation with adrenaline and cobra venom factor; and reduced platelet ATP, ATP/ADP ratio, serotonin content and -14C-serotonin release. In comparison to age- and sex-matched Wistar rats, FH rats have significantly prolonged partial thromboplastin time, shortened Russell's viper venom time and increased factor X and XI levels. Other coagulation screening tests and specific assays for fibrinogen, plasminogen and factors VII, VIII and IX were normal. Some age- and sex-related differences in coagulation and other parameters were observed within each rat strain. Plasma proteins, glycoproteins and ceruloplasmin (copper oxidase activity) showed no abnormalities, nor did initial studies of immunoglobulins and complement. However, FH rats have significantly lower glucose and higher cholesterol levels than comparable Wistar rats.
为了对其出血倾向进行遗传学和比较研究，培育了一个由五个原始家族及其六代后代组成的大群淡褐色带帽（FH）大鼠。这些大鼠出血素质的特征与Tschopp和Zucker最初在相关大鼠中报道的相似。FH大鼠的血块回缩、ADP诱导的血小板聚集和血小板ADP正常；对胶原的聚集反应可变；对肾上腺素和眼镜蛇毒因子的聚集反应最小；血小板ATP、ATP/ADP比值、5-羟色胺含量和-14C-5-羟色胺释放减少。与年龄和性别匹配的Wistar大鼠相比，FH大鼠的部分凝血活酶时间显著延长，蝰蛇毒时间缩短，因子X和XI水平升高。其他凝血筛查试验以及纤维蛋白原、纤溶酶原和因子VII、VIII和IX的特异性测定均正常。在每个大鼠品系中观察到了一些与年龄和性别相关的凝血及其他参数差异。血浆蛋白、糖蛋白和铜蓝蛋白（铜氧化酶活性）无异常，免疫球蛋白和补体的初步研究也无异常。然而，FH大鼠的血糖水平显著低于可比的Wistar大鼠，胆固醇水平则较高。
