Ramos J, Cerdán L F, Guevara M A, Amezcua C, Sanz A
Instituto de Neurociencias de la Universidad de Guadalajara, Jalisco Mexico.
Int J Neurosci. 2001 Jul;109(1-2):47-59. doi: 10.3109/00207450108986524.
This study was conducted in order to compare the EEG patterns of schizophrenics who do not respond to typical neuroleptics with those who do respond under typical neuroleptic medication and a group of controls. Absolute (AP) and relative power (RP), and inter- and intrahemispheric correlations were calculated. Nonresistant schizophrenics showed lower delta RP, higher alpha 1 AP and RP and higher correlation between prefrontal areas than the resistant ones and controls. Resistant schizophrenics showed lower alpha 2 RP, lower beta 1 and beta 2 in temporal but higher beta 2 AP and RP in occipital derivations, and higher intrahemispheric correlation between Fp2 and F4 and lower between F8 and T4 than the nonresistant and controls. The resistants also showed a higher antero-posterior beta 1 and beta 2 index than the controls. We concluded that the EEG pattern showed by the nonresistants may be associated with their good neuroleptic response that was not present in the resistant schizophrenics.
本研究旨在比较对典型抗精神病药物无反应的精神分裂症患者、对典型抗精神病药物有反应的精神分裂症患者以及一组对照者的脑电图模式。计算了绝对功率（AP）、相对功率（RP）以及半球间和半球内相关性。与有反应的精神分裂症患者及对照者相比，无反应的精神分裂症患者表现出较低的δ波RP、较高的α1波AP和RP以及前额叶区域之间较高的相关性。有反应的精神分裂症患者在颞叶表现出较低的α2波RP、较低的β1波和β2波，但在枕叶导联表现出较高的β2波AP和RP，且Fp2与F4之间的半球内相关性高于无反应的精神分裂症患者及对照者，而F8与T4之间的半球内相关性低于无反应的精神分裂症患者及对照者。有反应的精神分裂症患者还表现出比对照者更高的前后β1波和β2波指数。我们得出结论，无反应的精神分裂症患者所表现出的脑电图模式可能与其对抗精神病药物的良好反应有关，而有反应的精神分裂症患者则不存在这种情况。
