Snowdon J, Vaughan R, Miller R, Burgess E E, Tremlett P
Psychogeriatric Services, Central Sydney Health Service, Rozelle Hospital, NSW.
Med J Aust. 1995 Jul 17;163(2):70-2. doi: 10.5694/j.1326-5377.1995.tb126117.x.
To determine the pattern of use of psychotropic drugs in Sydney nursing homes.
Survey of data from medical records of residents and interviews with residents and staff.
Central Sydney Health Area, June to December 1993.
All residents of 46 of the 47 nursing homes in the western sector of the health area.
Psychotropic drugs used regularly or as required. Degree of cognitive impairment and depression rated on interview with residents, using Mini-Mental State Examination and Geriatric Depression Scale. Behavioural disturbances reported by staff.
Most residents (58.9%) were taking one or more psychotropic drugs regularly and another 7% were prescribed these drugs as required. Neuroleptics were taken regularly by 27.4% and as required by a further 1.4% (at least one dose in the previous four weeks), but doses were equivalent to more than 100 mg/day of chlorpromazine for only 8.8%. Neuroleptics were more likely to be given to residents with greater cognitive impairment and more disturbed behaviour. Other psychotropic drugs in regular use were: benzodiazepines (32.3%); hypnotics (26.6%); antidepressants (15.6%); and anxiolytics (8.6%). At least half of antidepressant doses were subtherapeutic. Of 874 residents who responded to a depression questionnaire, 30% scored as significantly depressed; one-third of these were taking antidepressants.
The percentage of residents in Central Sydney nursing homes who were taking neuroleptics, hypnotics or anxiolytics is among the highest reported from geriatric institutions around the world. Prescribing practices in Australian nursing homes need to be reviewed.
确定悉尼养老院中精神药物的使用模式。
对居民病历数据进行调查,并对居民和工作人员进行访谈。
悉尼中央健康区,1993年6月至12月。
健康区西区47家养老院中46家的所有居民。
定期或按需使用的精神药物。通过简易精神状态检查表和老年抑郁量表对居民进行访谈,评估认知障碍和抑郁程度。工作人员报告的行为障碍情况。
大多数居民(58.9%)定期服用一种或多种精神药物,另有7%按需开具这些药物。27.4%的居民定期服用抗精神病药物,另有1.4%按需服用(在前四周至少服用一剂),但剂量相当于氯丙嗪超过100毫克/天的仅占8.8%。抗精神病药物更有可能给予认知障碍更严重和行为更紊乱的居民。经常使用的其他精神药物有:苯二氮䓬类药物(32.3%);催眠药(26.6%);抗抑郁药(15.6%);以及抗焦虑药(8.6%)。至少一半的抗抑郁药剂量低于治疗水平。在874名回答抑郁问卷的居民中,30%的得分显示有明显抑郁;其中三分之一正在服用抗抑郁药。
悉尼中央养老院中服用抗精神病药、催眠药或抗焦虑药的居民比例是世界范围内老年机构报告的最高比例之一。澳大利亚养老院的处方做法需要审查。