Holmquist Ing-Britt, Svensson Bengt, Höglund Peter
Department of Nursing, Lund University, Sweden.
Eur J Clin Pharmacol. 2003 Nov;59(8-9):669-76. doi: 10.1007/s00228-003-0679-y. Epub 2003 Sep 27.
The aim of the present study was to map out what kind of psychotropic drugs are prescribed for elderly residents in assisted-living homes and how they relate to age, sex, form of living, psychiatric diagnosis, care needs and mental health status, and to identify factors of importance for their use; and to study the indication for treatment and the evaluation of the effects of treatment.
The study had a cross-sectional design and included one-third of all patients ( n=175) living in old-age homes or in nursing homes in a municipality in southern Sweden. Data concerning medication was obtained from medical records and included all psychotropic drugs prescribed the day the study started and the previous month. Need of care was assessed using Katz index, and mental health status was assessed using the Organic Brain Syndrome scale.
Of the study population, 128 (73%) used one or more psychoactive drug. Prescribed drugs were neuroleptics (16%), anxiolytics (32%), hypnotics, (45%), and anti-depressants (33%). A greater prescription of neuroleptics than anti-depressants was seen for those showing signs of depression, and caution with prescription of benzodiazepines was seen for those showing signs of dementia. An indication and evaluation of treatment was lacking in half of the cases. Treatment with psychiatric drugs existed for approximately 50% of those without a determined psychiatric diagnosis.
We have found a frequent use of neuroleptics, anxiolytics and hypnotics in the elderly, but an underprescription of anti-depressants appears to exist. There is a lack of documentation of indications and evaluations of psychotropic medication.
本研究旨在明确为生活辅助机构中的老年居民开具了何种精神药物,以及这些药物与年龄、性别、居住形式、精神疾病诊断、护理需求和心理健康状况之间的关系,并确定影响其使用的重要因素;同时研究治疗指征及治疗效果评估情况。
本研究采用横断面设计,纳入了瑞典南部一个市镇养老院或护理院中所有患者的三分之一(n = 175)。用药数据从病历中获取,包括研究开始当天及前一个月开具的所有精神药物。使用Katz指数评估护理需求,使用器质性脑综合征量表评估心理健康状况。
在研究人群中,128人(73%)使用了一种或多种精神活性药物。所开具的药物有抗精神病药(16%)、抗焦虑药(32%)、催眠药(45%)和抗抑郁药(33%)。对于有抑郁迹象的患者,抗精神病药的处方量多于抗抑郁药;对于有痴呆迹象的患者,开具苯二氮䓬类药物时需谨慎。半数病例缺乏治疗指征及治疗效果评估。在未确诊精神疾病的患者中约50%存在使用精神科药物进行治疗的情况。
我们发现老年人频繁使用抗精神病药、抗焦虑药和催眠药,但抗抑郁药的处方量似乎不足。精神药物的指征及评估缺乏记录。