Conner J T, Parson N, Katz R L, Wapner S, Bellville J W
Clin Pharmacol Ther. 1976 Jan;19(1):24-9. doi: 10.1002/cpt197619124.
Lorazepam, a new benzodiazepine, was compared with a standard surgical premedicant, pentobarbital. In a double-blind study in 128 patients, lorazepam, 2 and 4 mg, and pentobarbital, 50 and 100 mg, were given intravenously in a randomized sequence. Significant differences were noted; lorazepam was found to provide greater sedation, lack of recall, and greater antianxiety effect than pentobarbital. No significant adverse effects were noted following either drug. Vital signs remained stable.
