Fragen R J, Caldwell N
Anesth Analg. 1976 Nov-Dec;55(6):792-6. doi: 10.1213/00000539-197611000-00009.
Premedication with lorazepam (4 mg), diazepam (10 mg), and a placebo was compared in a randomized, double-blind study of 95 adult surgical patients. Comparisons were made of recall of a memory card and events of the operative day, relief of anxiety, degree of somnolence, effects on blood pressure and heart rate, and incidence of side effects. Lorazepam produced a significant lack of recall (antegrade amnesia) compared to the other agents. Lorazepam produced a greater antianxiety effect than placebo and a greater degree of somnolence than diazepam or placebo. Since no adverse effects on blood pressure or heart rate occurred, lorazepam appears to show promise as a premedicant.
在一项针对95名成年外科手术患者的随机双盲研究中，比较了使用劳拉西泮（4毫克）、地西泮（10毫克）和安慰剂进行术前用药的效果。对记忆卡回忆、手术日事件、焦虑缓解情况、嗜睡程度、对血压和心率的影响以及副作用发生率进行了比较。与其他药物相比，劳拉西泮导致明显的记忆缺失（顺行性遗忘）。劳拉西泮产生的抗焦虑作用比安慰剂更强，嗜睡程度比地西泮或安慰剂更高。由于未观察到对血压或心率的不良影响，劳拉西泮似乎有望成为一种术前用药。
