Conner J T, Katz R L, Bellville J W, Graham C, Pagano R, Dorey F
J Clin Pharmacol. 1978 May-Jun;18(5-6):285-92. doi: 10.1002/j.1552-4604.1978.tb02448.x.
Diazepam, 10 and 20 mg, and 2 and 4 mg lorazepam were studied as intravenous surgical premedicants in 120 patients. Relief of anxiety, sedation, patient acceptance, lack of recall, and side effects were the variables evaluated. Both diazepam and lorazepam proved to be excellent surgical premedicants. The basic difference between the two drugs is temporal. Both medications produce similar relief of anxiety, sedation, patient acceptance, and lack of recall. The clinical effects of intravenous diazepam peaks in 2 to 3 minutes and diminishes thereafter. Intravenous lorazepam has a latent period of 8 to 15 minutes, with increasing effects at 15 to 30 minutes.
在120例患者中，研究了10毫克和20毫克的地西泮以及2毫克和4毫克的劳拉西泮作为静脉注射手术前用药的效果。评估的变量包括焦虑缓解情况、镇静效果、患者接受度、无记忆现象以及副作用。地西泮和劳拉西泮都被证明是优秀的手术前用药。这两种药物的基本区别在于起效时间。两种药物在缓解焦虑、镇静、患者接受度和无记忆现象方面效果相似。静脉注射地西泮的临床效果在2至3分钟达到峰值，之后逐渐减弱。静脉注射劳拉西泮有8至15分钟的潜伏期，在15至30分钟时效果增强。
