Heisterkamp D V, Cohen P J
Br J Anaesth. 1975 Jan;47(1):79-81. doi: 10.1093/bja/47.1.79.
Sixty-nine patients undergoing regional anaesthesia were premedicated with either lorazepam (1, 2, 3 or 5 mg), diazepam (5 or 10 mg), pentobarbitone (50 mg) or placebo given i.v., on a double-blind, randomized basis. A simple yet rigorous protocol was used to test the effect of these drugs on anterograde recall. Lorazepam 3 and 5 mg was found to affect anterograde recall significantly. None of the other drugs tested affected recall.
69例接受区域麻醉的患者，在双盲、随机的基础上，静脉注射给予劳拉西泮（1、2、3或5毫克）、地西泮（5或10毫克）、戊巴比妥（50毫克）或安慰剂进行术前用药。采用一个简单但严格的方案来测试这些药物对顺行性记忆的影响。发现3毫克和5毫克的劳拉西泮对顺行性记忆有显著影响。所测试的其他药物均未影响记忆。
