Pan J W, Telang F W, Lee J H, de Graaf R A, Rothman D L, Stein D T, Hetherington H P
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
J Neurochem. 2001 Nov;79(3):539-44. doi: 10.1046/j.1471-4159.2001.00575.x.
We report the measurement of D-beta-hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo (1)H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acute infusion protocol to elevate plasma BHB levels from overnight fasted levels (0.20 +/- 0.10 mM) to a steady state value of 2.12 +/- 0.30 mM. At this level of hyperketonemia, we determined a tissue BHB level of 0.24 +/- 0.04 mM. No increases in brain lactate levels were seen in these data. The concentrations of BHB and lactate were both considerably lower in comparison with previous data acquired in fasted adult subjects. This suggests that up-regulation of the monocarboxylic acid transporter occurs with fasting.
我们报告了在对六名正常成年受试者急性输注β-羟基丁酸（BHB）期间对其大脑中BHB的测量结果。我们在枕叶使用高场活体氢磁共振（MR）波谱，并结合急性输注方案，将血浆BHB水平从空腹过夜水平（0.20±0.10 mM）提高到2.12±0.30 mM的稳态值。在这种酮血症水平下，我们测定的组织BHB水平为0.24±0.04 mM。这些数据中未观察到脑乳酸水平升高。与之前在空腹成年受试者中获得的数据相比，BHB和乳酸的浓度均显著降低。这表明单羧酸转运体的上调与禁食有关。
