Schweigert F J
Institute of Nutritional Science, University of Potsdam, Germany.
Curr Opin Clin Nutr Metab Care. 2001 Nov;4(6):477-81. doi: 10.1097/00075197-200111000-00002.
Inflammation causes a decrease in serum retinol and carotenoids as a consequence of the acute phase response of the organism. Under normal conditions both the acute phase response and the alterations in dynamics of retinol and carotenoids are transient. For both retinoids and carotenoids the adaptive benefit or the principal mechanism causing this decrease are not clear. Because nutritional deficiency results in a similar decrease of these nutritional biomarkers, it is necessary to be able to differentiate between inflammation or nutrition deficiency as the cause. This is of importance with regard to the supplementation of both critically ill patients and populations with a high infection load. The review covers several very recent publications shedding new light on and expanding our knowledge of the interaction between inflammation and the decrease in serum retinol and carotenoids.
炎症会导致血清视黄醇和类胡萝卜素减少，这是机体急性期反应的结果。在正常情况下，急性期反应以及视黄醇和类胡萝卜素动态变化的改变都是短暂的。对于类视黄醇和类胡萝卜素而言，这种减少所带来的适应性益处或主要机制尚不清楚。由于营养缺乏会导致这些营养生物标志物出现类似的减少，因此有必要能够区分炎症或营养缺乏作为病因。这对于重症患者和高感染负荷人群的补充治疗具有重要意义。这篇综述涵盖了几篇最新的出版物，这些出版物为炎症与血清视黄醇和类胡萝卜素减少之间的相互作用提供了新的线索，并扩展了我们对此的认识。
