Braae Olesen A, Bang K, Juul S, Thestrup-Pedersen K
Department of Dermatology, University Hospital of Aarhus, Denmark.
Acta Derm Venereol. 2001 Aug-Sep;81(4):277-81. doi: 10.1080/00015550152572921.
In this paper we describe the development and validation of a questionnaire for atopic dermatitis used in population surveys in Denmark. The Danish questionnaire was developed from the UK Working Party's questionnaire for atopic dermatitis and includes a severity score. The study included 61 children aged 3 to 14 years recruited from our Department of Dermatology, two kindergartens and a primary school. A validator was appointed to evaluate whether each child had current or previous atopic dermatitis. Compared to the validator's diagnosis, the sensitivity of the UK Working Party criteria was 90% (95% CI; 74-98) and the specificity was 97% (95% CI; 82-99). The criteria for atopic dermatitis have a satisfactory sensitivity and specificity for diagnosing current atopic dermatitis, but the natural course of the disease complicates the validation of investigational instruments. We suggest that future epidemiological studies aimed at establishing new knowledge on atopic dermatitis should include history, current symptoms and findings and a severity score.
在本文中，我们描述了一种用于丹麦人群调查的特应性皮炎问卷的编制与验证情况。这份丹麦问卷是在英国工作组的特应性皮炎问卷基础上编制而成的，其中包含一个严重程度评分。该研究纳入了从我们皮肤科、两所幼儿园和一所小学招募的61名3至14岁的儿童。指定了一名验证者来评估每个儿童目前或既往是否患有特应性皮炎。与验证者的诊断结果相比，英国工作组标准的敏感性为90%（95%置信区间；74 - 98），特异性为97%（95%置信区间；82 - 99）。特应性皮炎的诊断标准在诊断当前特应性皮炎方面具有令人满意的敏感性和特异性，但该疾病的自然病程使得调查工具的验证变得复杂。我们建议，未来旨在建立关于特应性皮炎新知识的流行病学研究应包括病史、当前症状和体征以及严重程度评分。
