Seibold J R, Harris J N
J Rheumatol. 1985 Feb;12(1):99-103.
Plasma beta-thromboglobulin (beta TG) levels were measured by radioimmunoassay in 61 patients with systemic sclerosis, 19 with carefully defined primary Raynaud's phenomenon, and 8 with Raynaud's phenomenon in suspected transition to systemic sclerosis. Elevated beta TG was present in 50 (82%) patients with systemic sclerosis but levels could not be correlated with duration or extent of disease nor any particular pattern of visceral involvement. Transitional Raynaud's patients had elevated beta TG in 7 (88%) cases, whereas results in patients with primary Raynaud's phenomenon were comparable to normal controls. beta TG, a sensitive measure of in vivo platelet activation, is useful in the differential diagnosis of Raynaud's phenomenon.
采用放射免疫分析法测定了61例系统性硬化症患者、19例明确诊断的原发性雷诺现象患者以及8例疑似系统性硬化症转变期雷诺现象患者的血浆β-血小板球蛋白（β-TG）水平。50例（82%）系统性硬化症患者的β-TG水平升高，但该水平与疾病持续时间、范围或任何特定的内脏受累模式均无相关性。7例（88%）转变期雷诺现象患者的β-TG水平升高，而原发性雷诺现象患者的检测结果与正常对照组相当。β-TG是体内血小板活化的敏感指标，有助于雷诺现象的鉴别诊断。
