抵抗是徒劳的：HIV-1对细胞机制的同化
Resistance is futile: assimilation of cellular machinery by HIV-1.
作者信息
Perez O D, Nolan G P
机构信息
Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, CA 94305, USA.
出版信息
Immunity. 2001 Nov;15(5):687-90. doi: 10.1016/s1074-7613(01)00238-2.
Abstract
HIV-1 budding appears to require Vps4 and Tsg101-two proteins that have links to endosomal sorting machinery. A picture emerges wherein divergent viruses recruit endosomal proteins like Tsg101 to gain access to ubiquitin processes that play a crucial role during viral budding.
摘要
HIV-1出芽似乎需要Vps4和Tsg101这两种与内体分选机制相关的蛋白质。由此呈现出一种情况，即不同的病毒招募诸如Tsg101之类的内体蛋白，以进入在病毒出芽过程中起关键作用的泛素化过程。
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