Xiong X, Saunders L D, Wang F L, Demianczuk N N
Department of Obstetrics and Gynecology, Laval University, City, Quebec, Canada.
Int J Gynaecol Obstet. 2001 Dec;75(3):221-8. doi: 10.1016/s0020-7292(01)00496-9.
To study prevalence, risk factors, and maternal and infant outcomes of women with gestational diabetes mellitus (GDM).
A retrospective cohort study was performed based on 111563 pregnancies delivered between 1991 through 1997 in 39 hospitals in northern and central Alberta, Canada. Multivariate logistic regression was used to estimate the odds ratios with 95% confidence intervals, and to control for confounding variables.
The prevalence of GDM was 2.5%. Risk factors for GDM included age >35 years, obesity, history of prior neonatal death, and prior cesarean section. Teenage mothers and women who drank alcohol were less likely to have GDM. Mothers with GDM were at increased risk of presenting with pre-eclampsia, premature rupture of membranes, cesarean section, and preterm delivery. Infants born to mothers with GDM were at higher risk of being macrosomic or large-for-gestational-age.
Specific conditions predispose to GDM which itself is associated with a significantly increased risk of maternal and fetal morbidity.
研究妊娠期糖尿病（GDM）女性的患病率、危险因素以及母婴结局。
基于1991年至1997年间在加拿大艾伯塔省北部和中部39家医院分娩的111563例妊娠进行回顾性队列研究。采用多因素逻辑回归来估计比值比及其95%置信区间，并控制混杂变量。
GDM的患病率为2.5%。GDM的危险因素包括年龄>35岁、肥胖、既往新生儿死亡史和既往剖宫产史。青少年母亲和饮酒女性患GDM的可能性较小。患有GDM的母亲发生子痫前期、胎膜早破、剖宫产和早产的风险增加。GDM母亲所生婴儿出现巨大儿或大于胎龄儿的风险更高。
特定情况易导致GDM，而GDM本身与母婴发病风险显著增加相关。
