Auger A P
Department of Physiology, University of Maryland, Baltimore School of Medicine, Baltimore, MD 21201, USA.
Reproduction. 2001 Dec;122(6):847-55. doi: 10.1530/rep.0.1220847.
Traditionally, steroid receptors were believed to be activated only by ligand binding; however, recent studies indicate that steroid receptors can also be activated by mechanisms that do not require ligand, referred to as ligand-independent activation. Specifically, progestin receptors can be activated in vitro and in vivo after treatment with neurotransmitters, such as dopamine, in the absence of progesterone. Furthermore, mating-related stimuli can also lead to ligand-independent activation of progestin receptors in female rat brain. This finding indicates that environmental stimuli can influence steroid receptor-dependent processes in the absence of circulating hormone. This review focuses on studies indicating that progestin receptors can be activated in the absence of progesterone to influence neuronal response and sexual behaviour in rodents.
传统上，人们认为类固醇受体仅通过配体结合来激活；然而，最近的研究表明，类固醇受体也可以通过不需要配体的机制被激活，这被称为非配体依赖性激活。具体而言，在没有孕酮的情况下，用神经递质（如多巴胺）处理后，孕激素受体可在体外和体内被激活。此外，与交配相关的刺激也可导致雌性大鼠大脑中孕激素受体的非配体依赖性激活。这一发现表明，在没有循环激素的情况下，环境刺激可以影响类固醇受体依赖性过程。本综述重点关注那些表明在没有孕酮的情况下孕激素受体可被激活以影响啮齿动物神经元反应和性行为的研究。
