Patton E E, Zon L I
Howard Hughes Medical Institute, Children's Hospital of Boston, 300 Longwood Avenue, Enders 750, Boston, Massachusetts 02115, USA.
Nat Rev Genet. 2001 Dec;2(12):956-66. doi: 10.1038/35103567.
Inventive genetic screens in zebrafish are revealing new genetic pathways that control vertebrate development, disease and behaviour. By exploiting the versatility of zebrafish, biological processes that had been previously obscured can be visualized and many of the responsible genes can be isolated. Coupled with gene knockdown and overexpression technologies, and small-molecule-induced phenotypes, genetic screens in zebrafish provide a powerful system by which to dissect vertebrate gene function and gene networks.
对斑马鱼进行的创新性基因筛选正在揭示控制脊椎动物发育、疾病和行为的新基因途径。通过利用斑马鱼的多样性，可以观察到以前模糊不清的生物学过程，并且可以分离出许多相关基因。结合基因敲低和过表达技术以及小分子诱导的表型，斑马鱼基因筛选提供了一个强大的系统，用于剖析脊椎动物的基因功能和基因网络。
