Wesson D E
Texas Tech University Health Sciences Center, Departments of Internal Medicine and Physiology, 3601 Fourth Street, Lubbock, TX 79430, USA.
Curr Hypertens Rep. 2001 Dec;3(6):511-6. doi: 10.1007/s11906-001-0014-x.
Hypertension and kidney function are intimately related, with each having significant influences on the other. Given the major role played by the kidney in maintenance of extracellular fluid volume and peripheral vascular resistance, the kidney is justifiably a target of investigation to determine its potential role in essential hypertension. Conversely, hypertension is associated with progressive renal failure, and hypertension-associated end-stage renal disease is the second leading cause of end-stage renal disease in the United States. It is therefore important that we continue to investigate the hypertension/renal relationship in an effort to better understand the determinants of essential hypertension and to prevent a major cause of end-stage renal disease.
高血压与肾功能密切相关，二者相互影响显著。鉴于肾脏在维持细胞外液量和外周血管阻力方面发挥的重要作用，肾脏理所当然成为研究其在原发性高血压中潜在作用的目标。相反，高血压与进行性肾衰竭相关，在美国，高血压相关的终末期肾病是终末期肾病的第二大主要病因。因此，继续研究高血压与肾脏的关系，对于更好地理解原发性高血压的决定因素以及预防终末期肾病的主要病因至关重要。
