• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新生儿疱疹治疗早期出现对阿昔洛韦耐药的单纯疱疹病毒。

Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum.

作者信息

Levin M J, Weinberg A, Leary J J, Sarisky R T

机构信息

Section of Infectious Diseases Department of Pediatrics University of Colorado School of Medicine Denver, CO, USA.

出版信息

Pediatr Infect Dis J. 2001 Nov;20(11):1094-7. doi: 10.1097/00006454-200111000-00021.

DOI:10.1097/00006454-200111000-00021
PMID:11734722
Abstract

Genotypic analysis of herpes simplex virus (HSV) DNA extracted from clinical specimens from a case of fatal disseminated neonatal HSV demonstrated that an infant developed an acyclovir-resistant HSV containing a mutation in the HSV thymidine kinase gene during the first seven days of acyclovir therapy.

摘要

从一例致命性播散性新生儿单纯疱疹病毒（HSV）临床标本中提取的HSV DNA进行基因分型分析显示，一名婴儿在阿昔洛韦治疗的前七天内出现了一种对阿昔洛韦耐药的HSV，其HSV胸苷激酶基因发生了突变。

相似文献

1
Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum.新生儿疱疹治疗早期出现对阿昔洛韦耐药的单纯疱疹病毒。
Pediatr Infect Dis J. 2001 Nov;20(11):1094-7. doi: 10.1097/00006454-200111000-00021.
2
Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed.对艾滋病患者中阿昔洛韦和膦甲酸钠治疗先后失败的单纯疱疹病毒分离株的DNA聚合酶基因和胸苷激酶基因的特征分析
J Infect Dis. 1999 Aug;180(2):487-90. doi: 10.1086/314900.
3
Infection due to acyclovir resistant herpes simplex virus in patients undergoing allogeneic hematopoietic stem cell transplantation.接受异基因造血干细胞移植患者中由耐阿昔洛韦单纯疱疹病毒引起的感染
Pathol Biol (Paris). 2001 Sep;49(7):553-8. doi: 10.1016/s0369-8114(01)00205-x.
4
Multiple herpes simplex virus infections with various resistance patterns in a matched unrelated donor transplant recipient.一名匹配无关供体移植受者发生的具有多种耐药模式的多重单纯疱疹病毒感染
Bone Marrow Transplant. 2001 Oct;28(8):799-801. doi: 10.1038/sj.bmt.1703233.
5
[Resistance of herpes simplex viruses to antiviral drugs].[单纯疱疹病毒对抗病毒药物的耐药性]
Pathol Biol (Paris). 1993 Feb;41(2):172-7.
6
Herpes simplex virus resistance to antiviral drugs.单纯疱疹病毒对抗病毒药物的耐药性。
J Clin Virol. 2003 Jan;26(1):29-37. doi: 10.1016/s1386-6532(02)00263-9.
7
[In vitro susceptibility study of herpes simplex virus to acyclovir and foscarnet. Are routine susceptibility studies necessary?].[单纯疱疹病毒对阿昔洛韦和膦甲酸钠的体外药敏研究。是否需要进行常规药敏研究？]
Enferm Infecc Microbiol Clin. 2002 Jan;20(1):25-7. doi: 10.1016/s0213-005x(02)72727-4.
8
Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient.感染免疫功能低下患者的阿昔洛韦和膦甲酸钠耐药单纯疱疹病毒的胸苷激酶和DNA聚合酶基因中的新突变。
J Clin Virol. 2002 Aug;25(2):165-70. doi: 10.1016/s1386-6532(02)00005-7.
9
In vitro activity of penciclovir against clinical isolates of acyclovir-resistant and foscarnet-resistant herpes simplex virus.喷昔洛韦对阿昔洛韦耐药和膦甲酸钠耐药单纯疱疹病毒临床分离株的体外活性
Antimicrob Agents Chemother. 1993 Oct;37(10):2241-3. doi: 10.1128/AAC.37.10.2241.
10
Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.由经病毒学证实的阿昔洛韦耐药单纯疱疹病毒 1 株引起的新生儿疱疹性脑炎。
J Clin Microbiol. 2013 Jan;51(1):356-9. doi: 10.1128/JCM.02247-12. Epub 2012 Oct 24.

引用本文的文献

1
The Impaired Neurodevelopment of Human Neural Rosettes in HSV-1-Infected Early Brain Organoids.HSV-1 感染早期大脑类器官中人类神经玫瑰花结的神经发育障碍。
Cells. 2022 Nov 9;11(22):3539. doi: 10.3390/cells11223539.
2
Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.90日龄以下婴儿肠道病毒和单纯疱疹病毒中枢神经系统感染：加拿大儿科感染研究协作网络（PICNIC）的一项研究
BMC Pediatr. 2020 May 26;20(1):252. doi: 10.1186/s12887-020-02151-4.
3
Safety of alternative antiviral agents for neonatal herpes simplex virus encephalitis and disseminated infection.
用于新生儿单纯疱疹病毒脑炎和播散性感染的替代抗病毒药物的安全性。
J Pediatr Pharmacol Ther. 2014 Apr;19(2):72-82. doi: 10.5863/1551-6776-19.2.72.
4
Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance.免疫功能低下儿童不同部位获得的单纯疱疹病毒（HSV）分离株的纵向特征分析：一种与耐药相关的新型HSV胸苷激酶突变
J Pediatric Infect Dis Soc. 2012 Jun;1(2):116-24. doi: 10.1093/jpids/pis009. Epub 2012 May 3.
5
Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain.由经病毒学证实的阿昔洛韦耐药单纯疱疹病毒 1 株引起的新生儿疱疹性脑炎。
J Clin Microbiol. 2013 Jan;51(1):356-9. doi: 10.1128/JCM.02247-12. Epub 2012 Oct 24.
6
Neonatal herpes simplex virus infections: where are we now?新生儿单纯疱疹病毒感染：我们现在在哪里？
Adv Exp Med Biol. 2011;697:221-30. doi: 10.1007/978-1-4419-7185-2_15.
7
Current management of Herpes simplex infection in pregnant women and their newborn infants: What's hot and what's not.孕妇及其新生儿单纯疱疹感染的当前管理：热门与冷门
Paediatr Child Health. 2003 Jul;8(6):339-42. doi: 10.1093/pch/8.6.339.
8
Vertical transmission of genital herpes: prevention and treatment options.生殖器疱疹的垂直传播：预防与治疗选择
Drugs. 2009;69(4):421-34. doi: 10.2165/00003495-200969040-00003.
9
Current management of Herpes simplex infection in pregnant women and their newborn infants: What's hot and what's not.孕妇及其新生儿单纯疱疹感染的当前管理：热门与冷门情况
Can J Infect Dis. 2003 Jul;14(4):197-200.
10
Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy.经过二十年抗病毒治疗后单纯疱疹病毒对阿昔洛韦和喷昔洛韦的耐药性。
Clin Microbiol Rev. 2003 Jan;16(1):114-28. doi: 10.1128/CMR.16.1.114-128.2003.