新生儿疱疹治疗早期出现对阿昔洛韦耐药的单纯疱疹病毒。
Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum.
作者信息
Levin M J, Weinberg A, Leary J J, Sarisky R T
机构信息
Section of Infectious Diseases Department of Pediatrics University of Colorado School of Medicine Denver, CO, USA.
出版信息
Pediatr Infect Dis J. 2001 Nov;20(11):1094-7. doi: 10.1097/00006454-200111000-00021.
Abstract
Genotypic analysis of herpes simplex virus (HSV) DNA extracted from clinical specimens from a case of fatal disseminated neonatal HSV demonstrated that an infant developed an acyclovir-resistant HSV containing a mutation in the HSV thymidine kinase gene during the first seven days of acyclovir therapy.
摘要
从一例致命性播散性新生儿单纯疱疹病毒（HSV）临床标本中提取的HSV DNA进行基因分型分析显示，一名婴儿在阿昔洛韦治疗的前七天内出现了一种对阿昔洛韦耐药的HSV，其HSV胸苷激酶基因发生了突变。
Zotero 插件