Goette D K, Elgart M, DeVillez R L
JAMA. 1975 Jun 2;232(9):934-7. doi: 10.1001/jama.232.9.934.
Three patients with biopsy-confirmed erythroplasia of Queyrat were treated with topically applied fluorouracil. The lesions cleared completely, and recurrence-free follow-up periods ranged from 20 to 60 months. There were normal histological findings in posttreatment biopsy specimens in two of the patients. A literature review yielded five additional cases successfully treated with fluorouracil applied topically. Patients with histologically confirmed erythroplasia of Queyrat should be afforded treatment with topically applied fluorouracil, as results appear to be superior to those of surgical or radiological treatment, with less morbidity.
三名经活检确诊为Queyrat增殖性红斑的患者接受了局部应用氟尿嘧啶的治疗。病变完全消退，无复发的随访期为20至60个月。其中两名患者的治疗后活检标本组织学检查结果正常。文献回顾又发现了另外五例成功接受局部应用氟尿嘧啶治疗的病例。对于组织学确诊为Queyrat增殖性红斑的患者，应给予局部应用氟尿嘧啶治疗，因为其效果似乎优于手术或放射治疗，且发病率更低。
