Lu H, Zhang D Z, Hu P J, Li Z S, Lu X H, Fang X C, Xiao S D
Shanghai Institute of Digestive Disease, Shanghai Second Medical University, Shanghai, China.
Aliment Pharmacol Ther. 2001 Dec;15(12):1975-9. doi: 10.1046/j.1365-2036.2001.01122.x.
The metronidazole resistance of Helicobacter pylori strains has increased rapidly.
To evaluate the efficacy and safety of new 1-week regimens containing ranitidine bismuth citrate, furazolidone and either amoxicillin or tetracycline.
One hundred and twenty patients with H. pylori-positive inactive duodenal ulcer or non-ulcer dyspepsia diagnosed by endoscopy were recruited randomly to receive one of two regimens for 7 days: ranitidine bismuth citrate, 350 mg b.d., furazolidone, 100 mg b.d., and either amoxicillin, 1000 mg b.d. (n=60), or tetracycline, 500 mg b.d. (n=60). H. pylori infection was identified by rapid urease testing and histology. 13C-Urea breath test was performed to evaluate the cure of H. pylori infection at least 4 weeks after completion of triple therapy.
The eradication rates of H. pylori by ranitidine bismuth citrate-furazolidone-amoxicillin and ranitidine bismuth citrate-furazolidone-tetracycline regimens were 82% and 85% (P > 0.05), respectively, by intention-to-treat analysis, and 85% and 91% (P > 0.05), respectively, by per protocol analysis. Adverse effects were mild in both ranitidine bismuth citrate-furazolidone-amoxicillin and ranitidine bismuth citrate-furazolidone-tetracycline groups.
One-week regimens containing ranitidine bismuth citrate, furazolidone and amoxicillin or tetracycline are well tolerated and effective for the eradication of H. pylori.
幽门螺杆菌菌株对甲硝唑的耐药性迅速增加。
评估含枸橼酸铋雷尼替丁、呋喃唑酮及阿莫西林或四环素的新型1周治疗方案的疗效和安全性。
招募120例经内镜诊断为幽门螺杆菌阳性的非活动性十二指肠溃疡或非溃疡性消化不良患者，随机接受两种治疗方案之一，疗程7天：枸橼酸铋雷尼替丁，350毫克，每日2次；呋喃唑酮，100毫克，每日2次；阿莫西林，1000毫克，每日2次（n = 60），或四环素，500毫克，每日2次（n = 60）。通过快速尿素酶试验和组织学鉴定幽门螺杆菌感染。在三联疗法完成后至少4周进行13C-尿素呼气试验，以评估幽门螺杆菌感染的根除情况。
按意向性分析，枸橼酸铋雷尼替丁-呋喃唑酮-阿莫西林和枸橼酸铋雷尼替丁-呋喃唑酮-四环素方案的幽门螺杆菌根除率分别为82%和85%（P>0.05）；按符合方案分析，分别为85%和91%（P>0.05）。枸橼酸铋雷尼替丁-呋喃唑酮-阿莫西林组和枸橼酸铋雷尼替丁-呋喃唑酮-四环素组的不良反应均较轻。
含枸橼酸铋雷尼替丁、呋喃唑酮及阿莫西林或四环素的1周治疗方案耐受性良好，对根除幽门螺杆菌有效。
