Altmann H
Arzneimittelforschung. 1975 Feb;25(2A):293.
Inhibition of endonuclease by d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) is discussed as a possible therapeutic principle of the antiinflammatory action in polyarthritis. Infections by 'slow viruses" and mycoplasma have to be considered as possible etiologic factors for rheumatoid arthritis. The incorporation of the viral or mycoplasmatic DNA into the genetic material of the host cell depends on the function of endonucleases, which can be inhibited by naproxen. The advantages and the drawbacks of this type of mechanism of action are discussed.
讨论了d - 2 -（6'-甲氧基 - 2'-萘基）-丙酸（萘普生）对核酸内切酶的抑制作用，这可能是多关节炎抗炎作用的一种治疗原理。必须考虑“慢病毒”和支原体感染作为类风湿性关节炎可能的病因。病毒或支原体DNA整合到宿主细胞的遗传物质中取决于核酸内切酶的功能，而萘普生可以抑制这种酶。本文讨论了这种作用机制的优点和缺点。
