Aihara Y, Takahashi Y, Kotoyori T, Mitsuda T, Ito R, Aihara M, Ikezawa Z, Yokota S
Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan.
J Allergy Clin Immunol. 2001 Dec;108(6):1035-9. doi: 10.1067/mai.2001.119914.
Food-dependent, exercise-induced anaphylaxis (FEIAn) is classified among the physical allergies. The pathophysiology of FEIAn remains unknown, as does the frequency of FEIAn in the general population.
We sought to study the epidemiology of FEIAn, especially its frequency in junior-high-school students in Yokohama, Japan.
A questionnaire asking about the occurrence of FEIAn in school students was sent to all 145 public junior-high-school nurses in Yokohama.
One hundred thirty-two junior-high-school nurses responded to the questionnaire, and 13 (11 boys and 2 girls) cases of FEIAn among 76,229 junior-high-school students were reported. In addition, 24 (12 boys and 12 girls) subjects with exercise-induced anaphylaxis (EIAn) were detected. From this survey, the frequency of FEIAn was 0.017% in this population, and its frequency was significantly higher in boys than in girls (P < .05). The frequency of EIAn was 0.031%, and there was no difference according to sex. Only one third of junior-high-school nurses had any knowledge of FEIAn. We also performed provocation tests in 5 of the 13 cases with FEIAn after obtaining informed consent from the students and their parents and were able to confirm the diagnosis.
This study showed that FEIAn and EIAn are relatively rare diseases among junior-high-school students in Yokohama. To avoid serious outcomes, we believe it is important that not only physicians but also school nurses and teachers of physical education be aware of these diseases.
食物依赖运动诱发的过敏反应（FEIAn）属于物理性过敏。FEIAn的病理生理学尚不清楚，其在普通人群中的发病率也未知。
我们试图研究FEIAn的流行病学，尤其是其在日本横滨初中生中的发病率。
向横滨所有145名公立初中护士发送了一份关于在校学生FEIAn发病情况的问卷。
132名初中护士回复了问卷，报告了76229名初中生中的13例（11名男孩和2名女孩）FEIAn病例。此外，还检测到24例（12名男孩和12名女孩）运动诱发的过敏反应（EIAn）受试者。通过这项调查，该人群中FEIAn的发病率为0.017%，男孩的发病率显著高于女孩（P < 0.05）。EIAn的发病率为0.031%，且无性别差异。只有三分之一的初中护士了解FEIAn。在获得学生及其家长的知情同意后，我们还对13例FEIAn病例中的5例进行了激发试验，并能够确诊。
本研究表明，FEIAn和EIAn在横滨初中生中是相对罕见的疾病。为避免严重后果，我们认为不仅医生，而且学校护士和体育教师了解这些疾病都很重要。
