Alvarado R G, Liu J Y, Zwolak R M
Dartmouth Medical School, Lebanon, NH, USA.
J Vasc Surg. 2001 Dec;34(6):1123-6. doi: 10.1067/mva.2001.118078.
Danazol is a synthetic androgenic steroid used clinically for the treatment of a wide variety of disorders. Although there is no extensive evidence that androgens are thrombogenic in humans, there are case reports of cerebral, coronary, and peripheral arterial thrombosis in young male athletes abusing anabolic-androgenic steroids. There are also two reported cases of arterial and venous thrombotic events attributed to danazol therapy. We report two additional cases of limb-threatening arterial thrombosis in patients undergoing danazol therapy, and suggest the possibility that danazol may be an independent risk factor for arterial thrombosis.
达那唑是一种合成雄激素类固醇，临床上用于治疗多种疾病。虽然没有广泛证据表明雄激素在人类中具有血栓形成作用，但有年轻男性运动员滥用合成代谢雄激素类固醇后发生脑、冠状动脉和外周动脉血栓形成的病例报告。也有两例报告称动脉和静脉血栓形成事件归因于达那唑治疗。我们报告另外两例接受达那唑治疗的患者发生危及肢体的动脉血栓形成病例，并提示达那唑可能是动脉血栓形成的一个独立危险因素。
