Boulton M, Rózanowska M, Rózanowski B
Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, UK.
J Photochem Photobiol B. 2001 Nov 15;64(2-3):144-61. doi: 10.1016/s1011-1344(01)00227-5.
The retina represents a paradox, in that, while light and oxygen are essential for vision, these conditions also favour the formation of reactive oxygen species leading to photochemical damage to the retina. Such light damage seems to be multi-factorial and is dependent on the photoreactivity of a variety of chromophores (e.g., vitamin A metabolites, lipofuscin, melanin, flavins, porphyrins, carotenoids) endogenous to the retina. The aim of this article is to provide a detailed review of our current understanding of the photochemistry and photobiology of these chromophores and to consider how they may contribute to retinal ageing and pathology.
视网膜是一个矛盾体，因为虽然光和氧气对视觉至关重要，但这些条件也有利于活性氧的形成，从而导致视网膜的光化学损伤。这种光损伤似乎是多因素的，并且取决于视网膜内多种发色团（例如维生素A代谢物、脂褐素、黑色素、黄素、卟啉、类胡萝卜素）的光反应性。本文的目的是详细综述我们目前对这些发色团的光化学和光生物学的理解，并探讨它们如何可能导致视网膜衰老和病变。
