School of Optometry and Vision Sciences, Cardiff University, Wales, UK.
Photochem Photobiol. 2012 Nov-Dec;88(6):1303-8. doi: 10.1111/j.1751-1097.2012.01240.x.
Light-induced injury to the retina resembles many features of several retinal degenerative diseases, particularly age-related macular degeneration. This Symposium-in-Print on Retinal Photodamage discusses the mechanisms involved and protective strategies to increase the retinal resistance to damage and/or to counteract its deleterious effects. Recent results help explaining the wavelength dependence of susceptibility of the retina to photodamage and different sites of the initial injury for shorter- and longer-wavelength light. Still, there are many unanswered questions pointing toward next directions in research so as to increase the understanding of the responses of the retina to photodamage and help to develop effective therapeutic approaches for retinal degenerations.
光诱导的视网膜损伤类似于几种视网膜退行性疾病的许多特征,特别是年龄相关性黄斑变性。本《视网膜光损伤专刊》讨论了相关的机制和保护策略,以提高视网膜对损伤的抵抗力和/或抵消其有害影响。最近的研究结果有助于解释视网膜对光损伤的敏感性的波长依赖性以及短波长和长波长光的初始损伤的不同部位。然而,仍有许多悬而未决的问题,这指向了进一步研究的方向,以便更好地了解视网膜对光损伤的反应,并有助于开发治疗视网膜退行性变的有效方法。