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尼日利亚的白化病。一项临床与社会学研究。

Albinism in Nigeria. A clinical and social study.

作者信息

Okoro A N

出版信息

Br J Dermatol. 1975 May;92(5):485-92.

PMID:1174464
Abstract

A study of 1000 Nigerian albinos, all of Negro stock, showed various types of albinism with their different modes of transmission--oculocutaneous, ocular and cutaneous. The much higher incidence among the more settled communities in the south, compared with the more nomadic communities in the north, may be related to greater inbreeding tendencies in the south. The sun and society are hostile to the albinos. Under the tropical sunshine, their melanin-deficient skin develops wrinkles, lentigines, actinic keratoses and epitheliomata from which they may die in early adult life or in middle age. Myopia and other ocular defects retard the progress of many albinos in school and they eventually drop out to seek disastrous menial outdoor occupations. Registering albinos early in life, assuring their families that albino defects are confined to the skin and eyes, advising on protective clothing and sun-screening agents, correcting myopia, assisting with indooor occupations, and early treatment of actinic keratoses and skin cancer should help many albinos to attain social acceptance and a ripe old age.

摘要

一项针对1000名尼日利亚白化病患者的研究,他们均为黑人血统,研究显示了白化病的各种类型及其不同的遗传方式——眼皮肤白化病、眼白化病和皮肤白化病。与北方游牧社区相比,南方定居社区的发病率要高得多,这可能与南方更大的近亲繁殖倾向有关。太阳和社会对白化病患者都不友好。在热带阳光下,他们缺乏黑色素的皮肤会出现皱纹、雀斑、光化性角化病和上皮瘤,他们可能在成年早期或中年时死于这些疾病。近视和其他眼部缺陷阻碍了许多白化病患者在学校的学业进展,他们最终辍学去从事危险的户外体力工作。在白化病患者幼年时进行登记,向其家人保证白化病缺陷仅限于皮肤和眼睛,就防护服和防晒剂提供建议,矫正近视,协助从事室内工作,以及早期治疗光化性角化病和皮肤癌,应该会帮助许多白化病患者获得社会认可并安享晚年。

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