尼日利亚白化病患者的染色体断裂和姐妹染色单体交换

Chromosome breaks and sister chromatid exchanges in albinos in Nigeria.

作者信息

Cervenka J, Witkop C J, Okoro A N, King R A

出版信息

Clin Genet. 1979 Jan;15(1):17-21. doi: 10.1111/j.1399-0004.1979.tb02024.x.

DOI:10.1111/j.1399-0004.1979.tb02024.x

Abstract

The prevalence of squamous cell carcinoma of the skin in albinos reaches approximately 90% in patients over 20 years of age in the vicinity of Enugu, Nigeria. Chromosome breaks and sister chromatid exchanges (SCE) were evaluated in tyrosinase-positive oculocutaneous albinos and pigmented controls of Ibo extraction who were life-long residents of Nigeria. No difference in the frequency of chromosomal breaks in 14 albinos compared to 6 pigmented controls, and no differences in the frequency of SCE in 9 albinos compared to 3 controls could be detected. Increased chromosomal abnormalities in lymphocytes do not appear to be assoicated with albinism or fulminating skin cancer present in albinos in the tropics.

摘要

在尼日利亚埃努古附近地区，20岁以上的白化病患者中皮肤鳞状细胞癌的患病率约为90%。对酪氨酸酶阳性的眼皮肤白化病患者和具有伊博族血统、长期居住在尼日利亚的有色素沉着的对照者进行了染色体断裂和姐妹染色单体交换（SCE）评估。在14名白化病患者与6名有色素沉着的对照者之间，未检测到染色体断裂频率的差异；在9名白化病患者与3名对照者之间，也未检测到SCE频率的差异。淋巴细胞中染色体异常增加似乎与热带地区白化病患者中存在的白化病或暴发性皮肤癌无关。