Jones D E, Norton D A, Harvey J, Davies D J
Br J Ophthalmol. 1975 Jun;59(6):304-7. doi: 10.1136/bjo.59.6.304.
The effect of Adrenaline 0.5 per cent and Guanethidine 2.5 per cent alone and in combination in reducing intraocular pressure in rabbits has been studied. Six rabbits were used and the efficiencies of 5 different dosage protocols was estimated both as intensity and duration of activity. The 5 dosage protocols were Adrenaline alone; Guanethidine alone; Adrenaline and Guanethidine together; Adrenaline followed in 30 min by ?Guanethidine; and Guanethidine followed in 30 min by Adrenaline. The single formulation containing both drugs appeared to be at least as efficient as the others. Eye drops containing 1 per cent Adrenaline and 5 per cent Guanethidine having sufficient stability for normal use have therefore been formulated.
研究了0.5%肾上腺素和2.5%胍乙啶单独使用及联合使用对降低兔眼压的效果。使用了6只兔子，并根据作用强度和持续时间评估了5种不同给药方案的效果。这5种给药方案分别是：单独使用肾上腺素；单独使用胍乙啶；肾上腺素和胍乙啶联合使用；肾上腺素30分钟后使用胍乙啶；胍乙啶30分钟后使用肾上腺素。含有两种药物的单一制剂似乎至少与其他制剂一样有效。因此，已配制出含有1%肾上腺素和5%胍乙啶且稳定性足以正常使用的眼药水。
