胍乙啶与肾上腺素滴眼液和单用1%肾上腺素治疗慢性单纯性青光眼的双盲比较
A double blind comparison of guanethidine-and-adrenaline drops with 1% adrenaline alone in chronic simple glaucoma.
作者信息
Mills K B, Ridgway A E
出版信息
Br J Ophthalmol. 1978 May;62(5):320-3. doi: 10.1136/bjo.62.5.320.
Abstract
We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3% and adrenaline 0.5% with that of adrenaline 1% alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma. The mean fall in ocular tension with the combined therapy was 10.67 mmHg, and with adrenaline 1% 6.31 mmHg, 24 hours after the commencement of phasing. The combined drop produced satisfactory control of ocular tension in all cases. These results indicate that a combined drop of guanethidine 3% and adrenaline 0.5% is a promising topical therapy for the control of chronic open-angle glaucoma.
摘要
我们展示了一项双盲试验的结果，该试验比较了3%胍乙啶与0.5%肾上腺素的单剂量组合和单独使用1%肾上腺素在降低慢性开角型青光眼患者眼压方面的疗效。在分阶段开始24小时后，联合治疗组眼压平均下降10.67 mmHg，1%肾上腺素组眼压平均下降6.31 mmHg。联合滴眼液在所有病例中都能使眼压得到满意控制。这些结果表明，3%胍乙啶与0.5%肾上腺素的联合滴眼液是控制慢性开角型青光眼的一种有前景的局部治疗方法。
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3
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Br J Ophthalmol. 1979 Dec;63(12):813-6. doi: 10.1136/bjo.63.12.813.
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Comparison of bretylium and guanethidine: tolerance, and effects on adrenergic nerve function and responses to sympathomimetic amines.溴苄铵与胍乙啶的比较：耐受性以及对肾上腺素能神经功能和对拟交感胺反应的影响。
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Action of drugs on the aqueous flow in man measured by fluorophotometry.通过荧光光度法测定药物对人体房水流出的作用。
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Guanethidine and adrenaline used in combination in chronic simple glaucoma.胍乙啶与肾上腺素联合用于慢性单纯性青光眼。
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