Mills K B, Ridgway A E
Br J Ophthalmol. 1978 May;62(5):320-3. doi: 10.1136/bjo.62.5.320.
We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3% and adrenaline 0.5% with that of adrenaline 1% alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma. The mean fall in ocular tension with the combined therapy was 10.67 mmHg, and with adrenaline 1% 6.31 mmHg, 24 hours after the commencement of phasing. The combined drop produced satisfactory control of ocular tension in all cases. These results indicate that a combined drop of guanethidine 3% and adrenaline 0.5% is a promising topical therapy for the control of chronic open-angle glaucoma.
我们展示了一项双盲试验的结果，该试验比较了3%胍乙啶与0.5%肾上腺素的单剂量组合和单独使用1%肾上腺素在降低慢性开角型青光眼患者眼压方面的疗效。在分阶段开始24小时后，联合治疗组眼压平均下降10.67 mmHg，1%肾上腺素组眼压平均下降6.31 mmHg。联合滴眼液在所有病例中都能使眼压得到满意控制。这些结果表明，3%胍乙啶与0.5%肾上腺素的联合滴眼液是控制慢性开角型青光眼的一种有前景的局部治疗方法。
