大鼠体内ε-（γ-L-谷氨酰基）-L-赖氨酸的代谢

Metabolism of epsilon-(gamma-L-glutamyl)-L-lysine in the rat.

Raczyński G, Snochowski M, Buraczewski S

Br J Nutr. 1975 Sep;34(2):291-6. doi: 10.1017/s0007114575000335.

Abstract

Study was made of the metabolism of epsilon-(gamma-L-glutamyl)-L[4,5-3H]lysine (GL) in the rat. 2. The compound was largely absorbed from the intestine and metabolized. Labelled lysine was incorporated into blood proteins. 3. In an in vitro experiment with everted sacs of rat small intestine, GL passed through the intestinal wall unchanged. 4. The results of comparative tests using homogenates of different body tissues indicated that the kidneys were particularly active in hydrolysing GL. Their activity was nine times greater than that of the liver and eighteen times greater than that of the small intestine.

摘要

对大鼠体内ε-（γ-L-谷氨酰基）-L-[4,5-³H]赖氨酸（GL）的代谢进行了研究。2. 该化合物大部分从肠道吸收并代谢。标记的赖氨酸被整合到血液蛋白质中。3. 在大鼠小肠外翻囊的体外实验中，GL未发生变化地穿过肠壁。4. 使用不同身体组织匀浆进行的对比试验结果表明，肾脏在水解GL方面特别活跃。其活性比肝脏高九倍，比小肠高十八倍。