Goyen M, Lauenstein T C, Herborn C U, Debatin J F, Bosk S, Ruehm S G
Department of Diagnostic Radiology, University Hospital Essen, Germany.
J Magn Reson Imaging. 2001 Nov;14(5):602-7. doi: 10.1002/jmri.1225.
To compare the effect on image quality of a 1.0 M gadolinium (Gd) chelate to that of a conventional 0.5 M Gd chelate, five healthy volunteers and seven patients with angiographically documented aorto-iliac disease underwent a mono-station three-dimensional magnetic resonance angiography (MRA) exam (Siemens SONATA, Erlangen, Germany) twice, once using Gadovist 1.0 and the other time using Magnevist as the contrast agent. All subjects received a fixed volume of Gadovist 1.0, corresponding to a dose between 0.1 and 0.15 mmol/kg body weight followed by a saline flush. For the Magnevist exam, the contrast agent volumes and flow rates were doubled. For both quantitative and qualitative analysis of the angiographic data sets, the arterial tree was divided into nine segments. 1 M Gadovist 1.0-enhanced three-dimensional MRA data sets were characterized by significantly higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) values compared to 0.5 M Magnevist-enhanced images. The data revealed mean SNR/CNR increases exceeding 70% (P < 0.01). Although there was no statistically significant difference in the rating of image quality (P > 0.05), the Gadovist 1.0 exam led to better delineation of the arterial morphology, especially of small vessels.
为比较1.0M钆（Gd）螯合物与传统0.5M Gd螯合物对图像质量的影响，5名健康志愿者和7名经血管造影证实患有主-髂动脉疾病的患者接受了单站三维磁共振血管造影（MRA）检查（西门子SONATA，德国埃尔朗根）两次，一次使用钆布醇1.0，另一次使用钆喷酸葡胺作为对比剂。所有受试者均接受固定体积的钆布醇1.0，对应剂量为0.1至0.15mmol/kg体重，随后进行生理盐水冲洗。对于钆喷酸葡胺检查，对比剂体积和流速加倍。为对血管造影数据集进行定量和定性分析，将动脉树分为九个节段。与0.5M钆喷酸葡胺增强图像相比，1M钆布醇1.0增强的三维MRA数据集具有显著更高的信噪比（SNR）和对比噪声比（CNR）值。数据显示平均SNR/CNR增加超过70%（P<0.01）。尽管图像质量评分无统计学显著差异（P>0.05），但钆布醇1.0检查能更好地描绘动脉形态，尤其是小血管的形态。
