Lennox E L, Draper G J, Sanders B M
Br Med J. 1975 Sep 27;3(5986):731-4. doi: 10.1136/bmj.3.5986.731.
The natural history and prognosis of retinoblastoma were analysed using data relating to the 268 cases registered during 1962-8 in England, Scotland, and Wales. The children were followed up for a minimum of four years; the proportion surviving for four years was 86%. The most important factors affecting survival rate were the stage of the tumour at diagnosis and the hospital of treatment. Of children surviving for three years after treatment only three died during the subsequent period of follow-up, which varied from one to seven years. Among children with retinoblastoma treated between 1949 and 1968 nine died between seven and 13 years later of other cancers: seven from osteosarcomas, one from angiosarcoma, and one from fibrosarcoma.
利用1962年至198年期间在英格兰、苏格兰和威尔士登记的268例视网膜母细胞瘤病例的数据，对视网膜母细胞瘤的自然病史和预后进行了分析。对这些儿童进行了至少四年的随访；四年生存率为86%。影响生存率的最重要因素是诊断时肿瘤的分期和治疗医院。治疗后存活三年的儿童中，只有三人在随后的一至七年随访期内死亡。在1949年至1968年接受治疗的视网膜母细胞瘤儿童中，有九人在七至十三年后死于其他癌症：七人死于骨肉瘤，一人死于血管肉瘤，一人死于纤维肉瘤。
