Friedman J H, Friedman H
Department of Clinical Neurosciences, Brown University Medical School, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island 20860, USA.
Mov Disord. 2001 Nov;16(6):1120-2. doi: 10.1002/mds.1201.
Fatigue affects about 50% of Parkinson's disease (PD) patients and is frequently one of its most disabling aspects. It does not correlate with disease severity or duration but does correlate with depression. Fatigue and depression are distinct symptoms and fatigue often fails to respond to antidepressants. The natural history of fatigue in PD is unknown, as no longitudinal studies have been published. This report describes the follow-up of subjects from our original study performed 9 years ago. Fatigue was a persistent problem for our subjects.
疲劳影响约50%的帕金森病（PD）患者，且常常是其最致残的方面之一。它与疾病严重程度或病程无关，但与抑郁相关。疲劳和抑郁是不同的症状，疲劳通常对抗抑郁药无反应。由于尚未发表纵向研究，PD中疲劳的自然病程尚不清楚。本报告描述了对9年前我们原始研究中的受试者的随访情况。疲劳对我们的受试者来说是一个持续存在的问题。
