Stewart B N, Hood C I, Block A J
Chest. 1975 Oct;68(4):486-92. doi: 10.1378/chest.68.4.486.
Twelve patients with hypoxemia associated with severe chronic obstructive pulmonary disease were treated with continuous portable oxygen therapy and have been followed up for a mean period of 25.2 months at sea level. Pulmonary function testing has revealed no further significant deterioration at long-term follow-up (17 months). After oxygen therapy was initiated, arterial carbon dioxide tension increased slightly, but decreased to pretreatment levels when patients were allowed to breathe room air. The electrocardiogram, which was unchanged at one month, has shown some reversal of cor pulmonale in five patients. Six patients have died, yielding a 56 percent survival rate at two-and-one-half years by the life table analysis. Five patients were autopsied, with possible oxygen toxicity being present in only one. The quality of life in our patients was improved and was especially represented by a reduction in hospital admissions for respiratory illness. We believe that continuous oxygen therapy is beneficial and worthwhile economically in certain patients.
12例伴有严重慢性阻塞性肺疾病的低氧血症患者接受了持续便携式氧疗，并在海平面进行了平均25.2个月的随访。肺功能测试显示，长期随访（17个月）时无进一步显著恶化。开始氧疗后，动脉二氧化碳分压略有升高，但当患者呼吸室内空气时降至治疗前水平。心电图在1个月时无变化，5例患者的肺心病有一定程度的逆转。6例患者死亡，通过寿命表分析，两年半时生存率为56%。5例患者接受了尸检，仅1例可能存在氧中毒。我们患者的生活质量得到了改善，尤其表现为因呼吸系统疾病住院次数减少。我们认为，持续氧疗对某些患者有益且在经济上是值得的。
