Zhang Y J, Abe T, Tanaka T, Yang C R, Kouno I
Faculty of Pharmaceutical Sciences, Nagasaki University, Bunkyo-Machi 1-14, Nagasaki 852-8521, Japan.
J Nat Prod. 2001 Dec;64(12):1527-32. doi: 10.1021/np010370g.
Six new ellagitannins, phyllanemblinins A-F (1-6), were isolated from Phyllanthus emblica, along with 30 known tannins and related compounds. Their structures were determined by spectral and chemical methods. Phyllanemblinins A (1) and B (2) were confirmed to be ellagitannins having a tetrahydroxybenzofuran dicarboxyl group and a hexahydroxydiphenoyl group, respectively, by chemical synthesis from furosin (8). Phyllanemblinin C (3) has a new acyl group at the glucose 2,4-positions and is structurally related to chebulagic acid. Phyllanemblinins D (4), E (5), and F (6) were found to be positional isomers of neochebuloyl 1(beta)-O-galloylglucose.
从余甘子中分离出6种新的鞣花单宁，即余甘鞣花素A - F（1 - 6），以及30种已知的单宁和相关化合物。通过光谱和化学方法确定了它们的结构。通过从呋喃素（8）进行化学合成，证实余甘鞣花素A（1）和B（2）分别是具有四羟基苯并呋喃二羧基和六羟基二苯甲酰基的鞣花单宁。余甘鞣花素C（3）在葡萄糖的2,4位有一个新的酰基，且在结构上与诃子鞣酸相关。发现余甘鞣花素D（4）、E（5）和F（6）是新诃子酰基1（β）-O - 没食子酰葡萄糖的位置异构体。
