Chang Fang-Rong, Hsieh Tian-Jye, Huang Ti-Lung, Chen Chung-Yi, Kuo Reen-Yen, Chang Yuh-Chwen, Chiu Hui-Fen, Wu Yang-Chang
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2002 Mar;65(3):255-8. doi: 10.1021/np010236w.
Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of Neolitsea acuminatissima. The structures of compounds 1-3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24-0.04 microg/mL. Compound 20 was marginally cytotoxic to Hep G2 cells.
从尖叶新木姜子的茎皮中分离出三种新的桉烷型倍半萜内酯，新木姜酮A - C（1 - 3），以及一种新的苄基异喹啉生物碱，新木姜子碱（5），同时还分离出27种已知化合物。化合物1 - 3和5的结构通过光谱和化学证据得以确定。化合物2、3和20对Hep 2,2,15细胞具有选择性抑制作用，IC50值在0.24 - 0.04μg/mL范围内。化合物20对Hep G2细胞具有轻微的细胞毒性。
