Thomas A G, Brodine S K, Shaffer R, Shafer M A, Boyer C B, Putnam S, Schachter J
Graduate School of Public Health, Department of Epidemiology and Biostatistics, San Diego State University, California, USA.
Obstet Gynecol. 2001 Dec;98(6):1117-23.
To apply urine-based ligase chain reaction for Chlamydia trachomatis (C. trachomatis) and Neisseria gonorrhoeae (N. gonorrhoeae) detection and standard urine-based pregnancy testing for Navy-enlisted women, and to compare the prevalence and epidemiologic correlates of these adverse reproductive outcomes.
Participants were surveyed and urine was collected for pregnancy testing using standard laboratory methods and detection of C. trachomatis and N. gonorrhoeae infection by ligase chain reaction. Self-administered surveys facilitated collection of demographics, sexual behavior, including contraceptive use, sexual partners, sexually transmitted disease, and pregnancy history.
Among 299 of 314 participants, the prevalence of chlamydial infection was 4.7% and of pregnancy was 9.7%, with 48.3% of the pregnancies unplanned. Chlamydia trachomatis infection was univariately associated with having a new sex partner within the last 6 months, more sexual partners, single marital status, condom use, drinking until passing out or vomiting in the past 30 days (alcohol misuse), and current pregnancy. Unplanned pregnancy was univariately associated with young age, single marital status, inconsistent condom use, having a new sex partner within the last 6 months, and more recent sexual partners. Among the pregnant women, four (13.8%) were infected with C. trachomatis.
The high rates of chlamydial infection and unplanned pregnancy found in this population of employed young women with ready access to health care and health education underscore the challenge of enhancing reproductive health via compliance with effective contraceptive and sexually transmitted disease prevention methods. This is a challenge that remains unmet.
对海军应征女性应用基于尿液的连接酶链反应检测沙眼衣原体（C. trachomatis）和淋病奈瑟菌（N. gonorrhoeae），并进行标准的基于尿液的妊娠检测，比较这些不良生殖结局的患病率及流行病学关联因素。
对参与者进行调查，并采集尿液，采用标准实验室方法进行妊娠检测，通过连接酶链反应检测沙眼衣原体和淋病奈瑟菌感染情况。自行填写的调查问卷有助于收集人口统计学信息、性行为信息，包括避孕措施使用情况、性伴侣、性传播疾病及妊娠史。
在314名参与者中的299名中，衣原体感染患病率为4.7%，妊娠患病率为9.7%，其中48.3%的妊娠为意外妊娠。沙眼衣原体感染单因素分析与过去6个月内有新性伴侣、性伴侣较多、单身婚姻状况、使用避孕套、过去30天内饮酒至昏迷或呕吐（酒精滥用）及当前妊娠相关。意外妊娠单因素分析与年轻、单身婚姻状况、避孕套使用不一致、过去6个月内有新性伴侣及近期有更多性伴侣相关。在孕妇中，4名（13.8%）感染了沙眼衣原体。
在这群有便捷医疗保健和健康教育资源的在职年轻女性中发现的衣原体感染和意外妊娠高发生率，凸显了通过遵守有效的避孕和性传播疾病预防方法来改善生殖健康的挑战。这一挑战仍未得到解决。
