Krueger James G
Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10021-6399, USA.
J Am Acad Dermatol. 2002 Jan;46(1):1-23; quiz 23-6. doi: 10.1067/mjd.2002.120568.
Psoriasis vulgaris is the most prevalent T-cell-mediated inflammatory disease in humans. The pathogenesis of psoriasis is linked to activation of several types of leukocytes that control cellular immunity and to a T-cell-dependent inflammatory process in skin that accelerates the growth of epidermal and vascular cells in psoriasis lesions. Critical steps in immunologic activation include Langerhans cell maturation (activation), T-cell activation, differentiation and expansion of type 1 T cells, selective trafficking of activated T cells to skin, and induction of an inflammatory cytokine and chemokine cascade in skin lesions. In turn, each of these steps offers an opportunity for intervention with engineered biologic therapeutics.
寻常型银屑病是人类中最常见的T细胞介导的炎症性疾病。银屑病的发病机制与控制细胞免疫的几种白细胞的激活以及皮肤中T细胞依赖性炎症过程有关，该炎症过程加速了银屑病皮损中表皮细胞和血管细胞的生长。免疫激活的关键步骤包括朗格汉斯细胞成熟（激活）、T细胞激活、1型T细胞的分化和扩增、活化T细胞向皮肤的选择性迁移以及皮损中炎症细胞因子和趋化因子级联反应的诱导。反过来，这些步骤中的每一个都为使用工程生物疗法进行干预提供了机会。
