Burdan F, Bełzek A
Pracownia Teratologii Doświadczalnej przy Katedrze i Zakładzie Anatomii Prawidłowej Człowieka AM w Lublinie.
Pol Merkur Lekarski. 2001 Sep;11(63):266-70.
Ibuprofen is a non-selective cyclooxygenase (COX) inhibitor with analgesic, antipyretic and antiinflammatory activity. Experimental, clinical and epidemiological studies, led on a wide scale, showed high therapeutically activity and good drug tolerability, especially for low doses in adult and children older then 6 months. Those data let to positioned ibuprofen to over-the-counter (OTC) drugs. However, unlike well-documented tolerability studies of the postnatal period the prenatal data are still unclear. Results of experimental studies showed ibuprofen-dependent: implantation disturbances, blocking of parturition, and contraction of ductus arteriosus what could produce persistent pulmonary hypertension. These data has been partially confirmed in human studies. Lack teratogenic effect was observed in in vivo animal studies. Gastroschisis is the only congenital ibuprofen-related malformation that was proved in big epidemiological human studies. Other congenital anomalies and disturbances, such as oligohydramnion, associated with maternal ibuprofen ingestion, and reported in available literature, have not been established in epidemiological studies.
布洛芬是一种具有镇痛、解热和抗炎活性的非选择性环氧化酶（COX）抑制剂。广泛开展的实验、临床和流行病学研究表明，其具有较高的治疗活性和良好的药物耐受性，尤其是低剂量对成人和6个月以上儿童而言。这些数据使得布洛芬被定位为非处方药。然而，与出生后时期有充分记录的耐受性研究不同，产前数据仍不明确。实验研究结果显示，布洛芬会导致着床障碍、分娩阻滞和动脉导管收缩，进而可能引发持续性肺动脉高压。这些数据在人体研究中得到了部分证实。在体内动物研究中未观察到致畸作用。腹裂是大型人类流行病学研究中证实的唯一与布洛芬相关的先天性畸形。现有文献中报道的其他与孕妇服用布洛芬相关的先天性异常和紊乱，如羊水过少，在流行病学研究中尚未得到证实。
