Merenda C, Sordat B, Mach J P, Carrel S
Int J Cancer. 1975 Oct 15;16(4):559-70. doi: 10.1002/ijc.2910160406.
Three out of five human endometrial carcinomas were successfully grafted into nude mice (BALB/c/nu/nu). Two of these tumors could be maintained by serial transplantation. The morphological characteristics displayed by the grafted tumors were comparable to those of the original carcinomas. Permanent cell lines were established from these two tumors. Reinjection of cells grown in vitro into nude mice produced nodules of identical histology as compared to original solid transplants. The influence of medroxyprogesterone acetate on tumor growth in vivo and cell proliferation in vitro was studied. This hormonal treatment did not produce any significant effect on tumor cells, either in vitro or in vivo, for the two endometrial carcinomas. After medroxyprogesterone administration, a slight but non-significant growth inhibition of the tumor cells in vitro was observed and the tumor transplants in vivo did not appear to be influenced. The experiments illustrate the possible use of this model for testing potential anti-cancer agents.
五例人类子宫内膜癌中有三例成功移植到裸鼠（BALB/c/nu/nu）体内。其中两例肿瘤可通过连续传代移植得以维持。移植瘤所呈现的形态学特征与原发癌相似。从这两例肿瘤中建立了永久细胞系。将体外培养的细胞重新注射到裸鼠体内，产生的结节组织学与原始实体移植瘤相同。研究了醋酸甲羟孕酮对体内肿瘤生长和体外细胞增殖的影响。对于这两例子宫内膜癌，这种激素治疗在体外和体内均未对肿瘤细胞产生任何显著影响。给予醋酸甲羟孕酮后，在体外观察到肿瘤细胞有轻微但不显著的生长抑制，且体内肿瘤移植似乎未受影响。这些实验说明了该模型在测试潜在抗癌药物方面的可能用途。
