Inalöz H S, Chowdhury M M, Knight A G
Department of Dermatology, University of Wales College of Medicine, Cardiff, UK.
J Eur Acad Dermatol Venereol. 2001 Sep;15(5):481-3. doi: 10.1046/j.1468-3083.2001.00302.x.
Lymphoepithelial neoplasms are biphasic tumours that contain both epithelial and lymphoid components. This heterogeneous group includes benign cutaneous lymphadenoma (CL), malignant lymphoepithelioma-like carcinoma of the skin and dermal thymus. We present two cases of CL in male subjects of 14 and 64 years of age. The latter man had a history of multiple basal cell carcinomas (BCCs) and solar keratoses. Histological sections of both tumours revealed similar features of an invasive non-ulcerated tumour with a mixed architecture of BCC and trichoepithelioma. Immunocytochemical examination revealed a biphasic epithelial tumour of follicular differentiation, possibly a variant of trichoepithelioma or a BCC. Within the epithelial islands there was a heavy infiltration that was confirmed as CD3-positive T cells and S-100-positive dendritic cells by immunocytochemistry.
淋巴上皮肿瘤是一种双相性肿瘤，包含上皮和淋巴样成分。这个异质性的肿瘤组包括良性皮肤淋巴结瘤（CL）、皮肤恶性淋巴上皮瘤样癌和皮肤胸腺。我们报告了两例分别为14岁和64岁男性的CL病例。后者有多发基底细胞癌（BCC）和日光性角化病病史。两个肿瘤的组织学切片显示出相似的特征，即一个浸润性非溃疡性肿瘤，具有BCC和毛发上皮瘤的混合结构。免疫细胞化学检查显示为一个具有滤泡分化的双相性上皮肿瘤，可能是毛发上皮瘤的一个变体或一个BCC。在上皮岛内部有大量浸润，免疫细胞化学证实为CD3阳性T细胞和S-100阳性树突状细胞。
