Jansen T, Romiti R, Kreuter A, Altmeyer P
Department of Dermatology and Allergology, Ruhr-University Bochum, Germany.
J Eur Acad Dermatol Venereol. 2001 Sep;15(5):484-5. doi: 10.1046/j.1468-3083.2001.00308.x.
Rosacea fulminans is a rare variant of rosacea conglobata that occurs almost exclusively in women well past adolescence. The aetiology is unknown, although immunological, hormonal, and vascular factors have been suggested. We report the case of a 17-year-old girl with rosacea fulminans that was temporally associated with daily ingestion of high-dose vitamin B supplements. The onset was sudden and cosmetically disabling. The eruption improved when the vitamin supplement was discontinued and a therapeutic regimen including isotretinoin and methylprednisolone was introduced. It seems appropriate to consider the possibility of such a vitamin B-triggered condition in cases of subjects presenting new or exacerbating facial eruptions.
暴发性酒渣鼻是聚合性酒渣鼻的一种罕见变体,几乎仅发生于青春期后的女性。病因不明,尽管有观点认为与免疫、激素和血管因素有关。我们报告一例17岁暴发性酒渣鼻女孩的病例,其发病时间与每日摄入高剂量维生素B补充剂有关。起病突然,对面部美观造成损害。停用维生素补充剂并采用包括异维A酸和甲泼尼龙的治疗方案后,皮疹有所改善。对于出现新发或加重面部皮疹的患者,考虑这种由维生素B引发疾病的可能性似乎是合理的。