鱼肝油对大鼠抗溃疡的作用。
Antiulcer activity of cod liver oil in rats.
机构信息
Krupanidhi College of Pharmacy, Bangalore, India.
出版信息
Indian J Pharmacol. 2008 Oct;40(5):209-14. doi: 10.4103/0253-7613.44152.
OBJECTIVE
Cod liver oil is used widely as a dietary supplement. The present study was carried out to evaluate the effect of cod liver oil (0.5 g/kg, p.o. and 1 g/kg, p.o.) on gastric and duodenal ulcers.
MATERIALS AND METHODS
The study was carried out on different gastric ulcer models such as acetic acid induced chronic gastric ulcers, pylorus ligation, indomethacin induced ulcers, stress induced ulcers and ethanol induced ulcers. The duodenal ulcers were induced using cysteamine hydrochloride (HCl). Ranitidine (50 mg/kg p.o.) and misoprostol (100 microg/kg, p.o.) were used as standard drugs.
RESULTS
Both doses of cod liver oil showed gastric ulcer healing effect in acetic acid induced chronic gastric ulcers, produced gastric antisecretory effect in pylorus-ligated rats and also showed gastric cytoprotective effect in ethanol-induced and indomethacin-induced ulcer. Cod liver oil also produced a significant reduction in the development of stress induced gastric ulcers and cysteamine induced duodenal ulcer. The high dose of cod liver oil (1 g/kg, p.o.) was more effective compared to the low dose (0.5 g/kg, p.o.).
CONCLUSION
Cod liver oil increases healing of gastric ulcers and prevents the development of experimentally induced gastric and duodenal ulcers in rats.
目的
鱼肝油被广泛用作膳食补充剂。本研究旨在评估鱼肝油（0.5 克/千克，口服和 1 克/千克，口服）对胃和十二指肠溃疡的影响。
材料和方法
本研究在不同的胃溃疡模型上进行，如乙酸诱导的慢性胃溃疡、幽门结扎、吲哚美辛诱导的溃疡、应激诱导的溃疡和乙醇诱导的溃疡。十二指肠溃疡使用半胱氨酸盐酸盐（HCl）诱导。雷尼替丁（50 毫克/千克，口服）和米索前列醇（100 微克/千克，口服）用作标准药物。
结果
鱼肝油的两个剂量均显示出对乙酸诱导的慢性胃溃疡的胃溃疡愈合作用，在幽门结扎大鼠中产生胃分泌抑制作用，并且在乙醇诱导和吲哚美辛诱导的溃疡中显示胃细胞保护作用。鱼肝油还显著减少应激诱导的胃溃疡和半胱氨酸诱导的十二指肠溃疡的发展。高剂量（1 克/千克，口服）鱼肝油比低剂量（0.5 克/千克，口服）更有效。
结论
鱼肝油可促进胃溃疡愈合，并预防大鼠实验性诱导的胃和十二指肠溃疡的发生。
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