Muzykewicz K J, Crowell E B, Hart A P, Schults M, Hill C G, Cooper S L
J Biomed Mater Res. 1975 Sep;9(5):487-99. doi: 10.1002/jbm.820090511.
Surface modification of cellulose acetate dialysis membranes was carried out by 60Co radiation induced graft copolymerization of the hydrogel, hydroxyethyl methacrylate (HEMA). The degree of grafting was controlled by varying the HEMA monomer concentration in the grafting solution and the radiation dose. A continuous flow platelet adhesion test was designed which allows testing under conditions more closely approximating hemodialysis than other small scale in vitro tests. Platelet adhesion on treated membranes fell substantially with increasing surface HEMA concentration. The presence of HEMA on the membrane surface did not affect the membrane activated clotting times significantly.
通过60Co辐射诱导甲基丙烯酸羟乙酯（HEMA）水凝胶接枝共聚，对醋酸纤维素透析膜进行表面改性。通过改变接枝溶液中HEMA单体浓度和辐射剂量来控制接枝度。设计了一种连续流动血小板粘附试验，与其他小规模体外试验相比，该试验能在更接近血液透析的条件下进行测试。随着表面HEMA浓度的增加，处理过的膜上的血小板粘附显著下降。膜表面HEMA的存在对膜激活凝血时间没有显著影响。
