dos Santos K S C R, Coelho J F J, Ferreira P, Pinto I, Lorenzetti S G, Ferreira E I, Higa O Z, Gil M H
Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 580, Bloco 13, 05508-900 São Paulo, Brazil.
Int J Pharm. 2006 Mar 9;310(1-2):37-45. doi: 10.1016/j.ijpharm.2005.11.019. Epub 2006 Jan 18.
Chitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate as chemical initiator. Evidence for graft copolymerization of the vinyl monomers onto chitosan was obtained by FTIR and DMTA. Swelling degree, cytotoxicity, thrombogenicity and haemolytic activity of these membranes were evaluated. Chitosan-graft-AA-graft-HEMA showed to be the best matrix for drug delivery systems than chitosan-graft-AA because it retains good swelling properties, but the content in HEMA has improved cytocompatibility, hemocompatibility and thrombogenic character.
以硝酸铈铵为化学引发剂，通过丙烯酸（AA）和甲基丙烯酸2-羟乙酯（HEMA）与壳聚糖的接枝共聚反应，制备了用于伤口愈合的壳聚糖基膜作为局部给药系统。通过傅里叶变换红外光谱（FTIR）和动态热机械分析（DMTA）获得了乙烯基单体与壳聚糖接枝共聚的证据。评估了这些膜的溶胀度、细胞毒性、血栓形成性和溶血活性。壳聚糖-接枝-AA-接枝-HEMA比壳聚糖-接枝-AA表现出更适合作为药物递送系统的基质，因为它保留了良好的溶胀性能，而且HEMA的含量改善了细胞相容性、血液相容性和血栓形成特性。
