Itamoto K, Taura Y, Wada N, Taga A, Takuma T, Matsumura H, Miyara T
The United Graduate School of Veterinary Science, Yamaguchi University, Japan.
J Vet Med A Physiol Pathol Clin Med. 2001 Nov;48(9):525-35. doi: 10.1046/j.1439-0442.2001.00381.x.
This study was designed to characterize the effect of medetomidine (Med) on canine electroencephalography (EEG), to evaluate the use of quantitative EEG for assessing sedation levels and to explore the correlation between the serum concentration of Med and the quantitative EEG. Four groups of dogs were given Med at doses of 20, 40, 80 and 160 microg/kg (Med-20, Med-40, Med-80 and Med-160 groups). Following Med administration, there was synchrony between each unipolar EEG lead. On EEG power spectrum analysis of the bipolar leads, all groups showed a significant depression of the 14-30 Hz components. The power of the 1-3 Hz component in the Med-80 and Med-160 groups was significantly increased, although there were few changes in the other groups. Similar results were obtained from raw data analysis. As a result of quantitative EEG analysis, spectrum edge frequency 90 analysis (SEP90) showed that the frequency was significantly reduced in all groups after Med administration. A dose-response effect was observed in all groups except for the Med-160 group. Both of these EEG analyses were significantly correlated with the serum concentration of Med. However, the result of the SPF90 analysis sugested a stronger correlation than that for median edge frequency analysis. In conclusion, care must be taken in veterinary clinical diagnoses when Med is used during EEG recording, as Med may cause increased activity in the low frequency band and a decrease in high frequency band activity. In addition, quantitative EEG analysis may be useful in assessing the depth of sedation and in further studies on Med administration.
本研究旨在表征美托咪定（Med）对犬脑电图（EEG）的影响，评估定量脑电图用于评估镇静水平的效用，并探索Med血清浓度与定量脑电图之间的相关性。四组犬分别给予20、40、80和160μg/kg剂量的Med（Med-20、Med-40、Med-80和Med-160组）。给予Med后，各单极EEG导联之间出现同步。对双极导联进行EEG功率谱分析时，所有组的14 - 30Hz成分均显著降低。Med-80组和Med-160组中1 - 3Hz成分的功率显著增加，而其他组变化不大。从原始数据分析中也获得了类似结果。定量脑电图分析结果显示，频谱边缘频率90分析（SEP90）表明给药后所有组的频率均显著降低。除Med-160组外，所有组均观察到剂量反应效应。这两种脑电图分析均与Med的血清浓度显著相关。然而，SPF90分析结果表明其相关性比中位边缘频率分析更强。总之，在EEG记录期间使用Med时，兽医临床诊断中必须谨慎，因为Med可能导致低频带活动增加和高频带活动减少。此外，定量脑电图分析可能有助于评估镇静深度以及进一步研究Med的给药情况。
