Robinson K J, Jones R S, Cripps P J
Department of Anaesthesia, University Clinical Departments, University of Liverpool.
J Small Anim Pract. 2001 Sep;42(9):444-7. doi: 10.1111/j.1748-5827.2001.tb02498.x.
Medetomidine at doses of 10, 20 or 30 microg/kg was administered along with 10 microg/kg buprenorphine intramuscularly to 48 dogs requiring sedation for various diagnostic or therapeutic procedures. The heart rate, respiratory rate and degree of sedation were recorded before and 30 minutes after administration of the drugs. Heart rate fell by a mean of 55 per cent and respiratory rate by a mean of 62 per cent. Mean sedation scores were increased in all groups. Administration of atipamezole at the end of the period of sedation produced rapid recoveries, with a mean time to standing of 12 minutes. Animals that were anaesthetised required much less thiopentone than the 10 mg/kg recommended after premedication with acepromazine maleate.
将剂量为10、20或30微克/千克的美托咪定与10微克/千克丁丙诺啡一起肌肉注射给48只因各种诊断或治疗程序而需要镇静的犬。在给药前和给药后30分钟记录心率、呼吸频率和镇静程度。心率平均下降55%，呼吸频率平均下降62%。所有组的平均镇静评分均有所提高。在镇静期结束时给予阿替美唑可使动物迅速恢复，平均站立时间为12分钟。与用马来酸乙酰丙嗪进行术前用药后推荐的10毫克/千克相比，麻醉的动物所需的硫喷妥钠要少得多。
