Department of Small Animal Surgery (Neurology), School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Department of Small Animal Surgery (Neurology), School of Veterinary Medicine, Azabu University, Kanagawa, Japan
Vet Rec. 2020 Jul 25;187(2):67. doi: 10.1136/vr.104947. Epub 2019 Nov 5.
Electroencephalography (EEG) is required for the diagnosis of canine idiopathic epilepsy as a highest confidence level of diagnosis by the International Veterinary Epilepsy Task Force; however, EEG is seldom used and a standardised assessment method has not been reported.
Interictal EEG was performed under medetomidine sedation in dogs with idiopathic epilepsy and in control dogs. Epileptiform discharge (ED) frequency was compared between dogs with more severe and less severe seizures during one month before EEG and control dogs.
All 10 dogs with more severe seizures had ED, as had 7 of 11 with less severe seizures. All epileptic dogs without ED had good long-term outcomes. ED frequency (number of ED per five minutes) was significantly higher in dogs with more severe (median, 4.5) than with less severe seizure (median, 0.46) and in the control dogs (median, 0.15). An ED frequency greater than 0.8 was considered to indicate epilepsy.
Interictal EEG in a light sleep state under medetomidine sedation had a high detection rate of ED, and ED frequency had a positive correlation with the recent severity of epileptic seizures. This allows interictal EEG recordings to be used as a simplified and objective test that may help to diagnose epilepsy and to assess the recent severity of the disease in dogs.
犬特发性癫痫的诊断需要脑电图（EEG）作为国际兽医癫痫工作组最高置信度的诊断；然而，EEG 很少使用，也没有标准化的评估方法。
在镇静状态下对特发性癫痫犬和对照犬进行了发作间期 EEG 检查。比较了 EEG 前一个月癫痫发作更严重和更轻微的犬与对照犬之间癫痫样放电（ED）的频率。
所有癫痫发作更严重的 10 只犬均出现 ED，癫痫发作更轻微的 11 只犬中有 7 只出现 ED。所有无 ED 的癫痫犬均有良好的长期预后。ED 频率（每 5 分钟 ED 数）在癫痫发作更严重（中位数 4.5）的犬中显著高于癫痫发作更轻微（中位数 0.46）和对照犬（中位数 0.15）。ED 频率大于 0.8 被认为表示癫痫。
在镇静状态下的浅睡眠期间进行发作间期 EEG 具有较高的 ED 检测率，ED 频率与近期癫痫发作的严重程度呈正相关。这使得发作间期 EEG 记录可作为一种简化和客观的测试，有助于诊断癫痫和评估犬的近期疾病严重程度。
