Syme H M, Scott-Moncrieff J C, Treadwell N G, Thompson M F, Snyder P W, White M R, Oliver J W
Department of Veterinary Clinical Sciences, School Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
J Am Vet Med Assoc. 2001 Dec 15;219(12):1725-8, 1707-8. doi: 10.2460/javma.2001.219.1725.
An 11-year-old spayed female Labrador Retriever and a 9-year-old castrated male miniature Poodle were evaluated because of clinical signs of hyperadrenocorticism. Cortisol testing did not support a diagnosis of hypercortisolemia in either dog; however, imaging studies revealed unilateral adrenal tumors in both dogs. Serum concentrations of 17-hydroxyprogesterone, progesterone, and estradiol were high in both dogs, and androstenedione concentrations were also high in 1 dog. It is suspected that sex hormone secretion by the adrenal tumors in these dogs resulted in clinical signs of hyperadrenocorticism. Clinical signs and hormonal abnormalities resolved in the male dog after surgical resection of the tumor. There was no improvement in clinical signs after treatment with mitotane in the female dog, which died 2 months after diagnosis. Histologic evaluation confirmed the presence of adrenocortical carcinoma in both dogs.
一只11岁已绝育的雌性拉布拉多寻回犬和一只9岁已去势的雄性迷你贵宾犬因出现肾上腺皮质功能亢进的临床症状而接受评估。皮质醇检测不支持这两只犬患有高皮质醇血症的诊断；然而，影像学研究显示两只犬均有单侧肾上腺肿瘤。两只犬的血清17-羟孕酮、孕酮和雌二醇浓度均升高，其中1只犬的雄烯二酮浓度也升高。怀疑这些犬的肾上腺肿瘤分泌性激素导致了肾上腺皮质功能亢进的临床症状。雄性犬在手术切除肿瘤后临床症状和激素异常消失。雌性犬用米托坦治疗后临床症状无改善，诊断后2个月死亡。组织学评估证实两只犬均存在肾上腺皮质癌。
